Pancreatic cancer phd thesis

Pancreatic cancer phd thesis

Pancreatic cancer phd thesis for examples of argumentation essays Introduction of thesis about education and pancreatic cancer phd thesis. Student writing and learning in vocational Dissertation topics for educational management. If playback doesn't begin shortly, try restarting your device Our Pancreatic Cancer Phd Thesis writing staff is working to meet your needs and expectations and take care of your writing assignment! Prices starting from High School - $10 College - $14 University - $17 Master's - $22 Ph.D. - $26 High School - $10 per page/10() protocol. Without these diagnostic tools, many pancreatic cancer cases in the past or even at present in low-income countries, might have been improperly diagnosed and registered. This PhD thesis aims to investigate the diagnostic and therapeutic role of endoscopic ultrasound-guided interventions in the management of patients with pancreatic cancer

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Ali, Asif Biomarkers for pancreatic cancer: identification, validation and clinical application. PhD thesis, University of Glasgow. Pancreatic cancer is common and aggressive: the main type is pancreatic ductal adenocarcinoma PDAC.

Although imaging may be highly suggestive of PDAC, a pathological diagnosis is preferred prior pancreatic cancer phd thesis definitive treatment; therefore tissue samples are required. Cytology samples are obtained at endoscopy. Cytological analysis requires the identification of different cell types and in particular the distinction of malignant pancreatic epithelial cells from reactive pancreatic cells and other gastrointestinal contaminants.

This requires experience and expertise and can be difficult. A tissue diagnosis is not achieved in a significant proportion of PDAC cases. Hence, an unmet clinical need exists for the diagnosis of PDAC from cytological samples, pancreatic cancer phd thesis.

One potential way of improving the cytological diagnosis is to use immunohistochemistry IHC biomarkers as an adjunct to cytology in difficult to diagnose cases.

Diagnostic IHC pancreatic cancer phd thesis have been investigated, but to date none has entered into routine clinical practice. The aim of this study was to improve the diagnosis of PDAC from cytology samples. It is hoped that the identification and validation of IHC biomarkers in PDAC will help their clinical translation, pancreatic cancer phd thesis.

For biomarker identification a meta-analysis of potential IHC diagnostic biomarkers investigated in PDAC was performed. Sixteen biomarkers were quantified in meta-analysis and the highest ranked biomarkers were KOC, maspin, SP, mesothelin and MUC1.

These biomarkers have not entered into clinical practice partly because they were investigated in separate studies with relatively small sample sizes and without a uniform and pancreatic cancer phd thesis appropriate cut-off. Biomarkers identified in the meta-analysis were validated in a resection cohort from patients with pancreatico-biliary adenocarcinoma.

The aim was to identify better biomarkers and cut-offs that could potentially be investigated in cytology samples, pancreatic cancer phd thesis. KOC, SP, mesothelin and MUC1 were investigated in one set of tissue microarrays, while maspin was investigated in another set. Clinical translation of biomarker requires a reliable and reproducible cut-off for interpretation of IHC.

We identified three cut-offs for investigation to establish a consensus based cut-off s that could potentially be used pancreatic cancer phd thesis pathologists for PDAC and other cancers. Seven pathologists participated in this study.

The inter- and intra-observer agreements using the three cut-offs were reasonably good. Finally, KOC, maspin, mesothelin and SP were investigated in archival cytology samples with the aim to generate a diagnostic panel which could potentially help as an adjunct to cytology.

But no staining was observed for SP. Their diagnostic accuracies approach those of optimal conventional cytology. These markers may be appropriate for further clinical validation and potentially routine use in difficult cases. Skip to main content Accessibility information. Site navigation Study Research About us Student life Alumni Support us Contact. Site tools A-Z Lists. Home Enlighten Theses. Enlighten: Theses. Biomarkers for pancreatic cancer: identification, validation and clinical application.

Full text available as: Preview. Back to top. Contact us The University of Glasgow is a registered Scottish charity: Registration Number SC PDF Download 7MB Preview. Dr Asif Ali.

Kim's Story - Pancreatic Cancer Survivor

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For the scholarship, phd thesis in pancreatic cancer students are required to submit an essay that explains how they overcame significant obstacles to complete or continue school. Personal essay application college law essay paragraph structure how to transition from one paragraph to the next in an essay protocol. Without these diagnostic tools, many pancreatic cancer cases in the past or even at present in low-income countries, might have been improperly diagnosed and registered. This PhD thesis aims to investigate the diagnostic and therapeutic role of endoscopic ultrasound-guided interventions in the management of patients with pancreatic cancer Pancreatic carcinoma or pancreatic cancer (PaCa) is an insidious disease with a prognosis of 6- to month survival time for a late stage diagnosis. This problem has become crucial given that no study to date had been able to establish a definitive association between independent factors (other than a few diseases) and the survival rate of pancreatic blogger.com: Sylvester Lewis